Liliya Frolova

Liliya Frolova, PhD

Associate Research Professor

Chemistry


 

Education

Postdoctoral Fellowship, Braunschweig University of Technology, Braunschweig, Germany.

Ph.D., Chemistry, V.I. Ulyanov-Lenin Kazan State University, 1992

M.Sc., Organic Chemistry, V.I. Ulyanov-Lenin Kazan State University, 1988

Keywords

Heterocyclic compounds, natural compounds, medicinal chemistry, drug design and development, novel reactions, novel synthetic methods, drug-resistant cancers, drug-resistant bacteria, inorganic-organic hybrid materials, graphene, graphite

Research Interests

Research in Dr. Frolova's laboratory divides between two main streams: development of novel anticancer and antibacterial drugs on the basis of heterocyclic mimetics of natural compounds, and study of chemical reactivity of graphene, graphite, and transition metal nano particles with organic reagents for the development of novel inorganic-organic hybrid materials for different purposes. The medicinal chemistry research projects focus on drug-resistant bacteria and drug-resistant cancers including apoptos-resistant, multidrug-resistant cancers and cancers with dismiss prognoses (glioma, melanoma and others). Using rational drug design and library screening they develop novel antibacterial and anticancer agents with the focus on drug-resistant cultures. To achieve these goals, our group often develops novel synthetic pathways of general significance. Also her team study new drug delivery options for our biologically active compounds in collaboration with Dr. Michaelann Tartis (Department of Chemical Engineering, New Mexico Tech). She collaborates closely with Dr. Rogelj in the Biology Department of NM Tech as well as with other chemists and biologists across USA and Europe. The other direction of their research, novel inorganic-organic hybrid materials, grew up from the collaborative investigations (Dr. Nikolai Kalugin, Department of Materials and Metallurgical Engineering in New Mexico Tech) of the possibility of organic modification of graphene, graphite and transition metal particles in different organic reactions. She made several successful organic modifications of graphene and graphite surfaces. Also some interesting combinations of organic compounds with transition metal particles were developed.

Recent Publications

Microtubule‐Targeting 7‐Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multi‐Drug Resistance Proteins. Dasari, R.; Błauż, A.; Medellin, D.C.; Kassim, R.M.; Viera, C.; Santarosa, M.;  Alet E. van der Westhuyzen, Willem A. L. van Otterlo, Taryn Olivas, Tugba Yildiz, Tania Betancourt, Charles B. Shuster,  Snezna Rogelj, Błażej Rychlik, Todd Hudnall, Liliya V. Frolova and Alexander Kornienko, ChemMedChem.,  2019, 14, 322.

Photo-physical properties of substituted 2,3-distyryl indoles: Spectroscopic, computational and biological insights. Rajapakshaa, R.D.; Turner, D.N.; Vigila, J.; Frolova, L.V.; Altiga, J.A.; Rogelj, S.; Ranasinghea, M.I. J. Photochem. Photobiol. A, 2019, 376, 73.

Metal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo-trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamates. Maslivetc, V.; Frolova, L.; Rogelj, S.; Maslivetc, A.; Rubina, M.; Rubin, M. J. Org. Chem., 2018, 83, 13743.

Surface-modified three-dimensional graphene nanosheets as a stationary phase for chromatographic separation of chiral drugs. Candelaria, L.; Frolova, L.V.; Kowalski, B.M., Artyushkova, K.; Serov, A.; Kalugin, N.G.  Scientific Reports, 2018, 8, 14747.

Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria. Edwards, L.; Turner, D.; Champion, C.; Khandelwal, M.; Zingler, K.; Stone, C.; Rajapaksha, R.; Yang, J.; Ranasinghe, M.; Frolova, L.; Rogelj, S. Bioorg. Med. Chem. Lett., 2018, 28, 1879.