Dr. Rodolfo Tello-Aburto

Rodolfo Tello-Aburto, PhD

Assistant Professor

Chemistry


Research Group Homepage

Education

Postdoctoral Fellow, New Mexico State University, 2013

Postdoctoral Associate, University of Minnesota, 2011

Ph.D. Medicinal and Natural Products Chemistry, University of Iowa, 2008

M.Sc. Organic Chemistry, Universidad Nacional Autonoma de Mexico, 2002

B.Sc. Chemistry-Pharmacy-Biology. Universidad Veracruzana, 1997

Keywords

Total Synthesis, Natural Products, Synthetic Methodology

Research Interests

Our lab seeks to use chemistry to advance the understanding of biological processes involved in disease inception, progression and resistance development. Using natural products as inspiration and starting point, we are developing bioactive molecules with improved activities and desirable pharmacological profiles. The design of novel synthetic methodologies and their application to concise and practical synthetic sequences in our lab will allow rapid access to these biologically relevant molecules and their analogs.

Divisions

Biomedical and Medicinal

Recent Publications

Rodolfo Tello-Aburto, Alyssa N. Lucero, and Snezna Rogelj. A Catalytic Approach to the MH-031 Lactone: Application to the Synthesis of Geralcin Analogs. Tetrahedron Lett. 2014, 55, 6266-6268.

Suneet Mehrotra, Brendan M. Duggan, Rodolfo Tello-Aburto, Tara D. Newar, William H. Gerwick, Thomas F. Murray and William A. Maio. Detailed Analysis of (–)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists. J. Nat. Prod. 2014, 77, 2553-2560.

Rodolfo Tello-Aburto, Kyle A. Kalstabakken, and Andrew M. Harned. Ligand and Substrate Effects During Pd-Catalyzed Cyclizations of Alkyne-Tethered Cyclohexadienones. Org. Biomol. Chem. 2013, 11, 5596–5604.

Leticia Minor-Villar, Rodolfo Tello-Aburto, Horacio F. Olivo, Aydee Fuentes, Moises Romero-Ortega. Desulfurization–Oxygenation of Chiral 1,3-Thiazolidine-2-thiones and 1,3-Oxazolidine-2-thiones Using Propylene Oxide and Microwave Irradiation. Synlett. 2012, 23, 2835–2839.

Rodolfo Tello-Aburto, Tara D. Newar and William A. Maio. Evolution of a Protecting-Group-Free Total Synthesis: Studies en Route to the Neuroactive Marine Macrolide (–)-Palmyrolide A. J. Org. Chem. 2012, 77, 6271–6289.

Rodolfo Tello-Aburto, Emily M. Johnson, Cheyenne K. Valdez and William A. Maio. Asymmetric Total Synthesis and Absolute Stereochemistry of the Neuroactive Marine Macrolide Palmyrolide A. Org. Lett. 2012, 14, 2150–2153. [Highlighted in Synfacts 2012, 8 (7), 708]